ELR positive CXCL chemokines are highly expressed in an animal model of ulcerative colitis

ELR positive CXCL chemokines are highly expressed in an animal model of ulcerative colitis
Authors Mohammad Amin Boshagh, Poorya Foroutan, Mohammad Raman Moloudi, Shohreh Fakhari, Parisa Malakouti, Bahram Nikkhoo, Ali Jalili
Publication date 2019/6/25
Journal Journal of inflammation research
Pages 167-174
Publisher Taylor & Francis
Description Background
The presence of neutrophil-rich inflammation in colon tissues of patients with ulcerative colitis (UC) is one of the most important histological characteristics of this disease. However, the expression of CXCL chemokines governing the infiltration of neutrophils in UC has not been well elucidated.
Materials and methods
In this experimental study, the UC model was induced in Wistar rats by administration of 2 mL 4% acetic acid into the large colon through the rectum. Animals were anesthetized after 48 hrs; their colon tissue samples were isolated for macroscopic and histopathological examinations. The expression of CXCL family was assessed by reverse transcription polymerase chain reaction (qRT-PCR) technique.
Results
Heavy infiltration of neutrophils, coagulation necrosis, and ulcers were observed in H&E staining, which pathologically proved the UC model. qRT-PCR results showed that ELR+ CXC…
Total citations Cited by 28
Scholar articles ELR positive CXCL chemokines are highly expressed in an animal model of ulcerative colitis
MA Boshagh, P Foroutan, MR Moloudi, S Fakhari… – Journal of inflammation research, 2019
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