Simultaneous blockade of TIGIT and HIF-1a induces synergistic anti-tumor effect and decreases the growth and development of cancer cells

Authors Mehrdad Fathi, Simin Bahmanpour, Asal Barshidi, Hossein Rasouli, Fariba Karoon Kiani,
Armin Mahmoud Salehi Khesht, Sepideh Izadi, Bentolhoda Rashidi, Shiva Kermanpour,
Roya Mokhtarian, Vahid Karpisheh, Hadi Hassannia, Hamed Mohammadi, Ali Jalili, Farhad Jadidi-Niaragh
Publication date 2021/12/1
Journal International immunopharmacology
Volume 101
Pages 108288
Publisher Elsevier
Description Purpose
T-cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint that is overexpressed on both immune cells and some cancer cells. TIGIT can alter the anti- tumor responses inside the tumor microenvironment. Hypoxia-inducible factor 1-alpha (HIF-1a) plays a significant role in the TME and involves suppressing the anti-tumor responses. Under hypoxic conditions, HIF-1a can enhance the expression of different immune checkpoints. Accordingly, hypoxic TME and TIGIT overexpression cause cancer development. Thus, we decided to inhibit tumor cell expansion by inhibiting TIGIT and HIF-1a molecules and discovering the relationship between TIGIT and HIF-1a. Methods
In this research, we utilized superparamagnetic iron oxide-based NPs (SPIONs) combined with chitosan lactate (CL) and folic acid (FA) nanoparticles (NPs) loaded with TIGIT-siRNA and HIF-1a-siRNA for suppressing TIGIT and HIF…
Total citations Cited by 16
2022 2023
Scholar articles Simultaneous blockade of TIGIT and HIF-1a induces synergistic anti-tumor effect and decreases the growth and development of cancer cells
M Fathi, S Bahmanpour, A Barshidi, H Rasouli… – Intern