Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran
Authors Nasrin Moghimi, Sherko Nasseri, Farzad Ghafouri, Ali Jalili
Publication date 2021/5
Journal International Journal of Rheumatic Diseases
Volume 24
Issue 5
Pages 694-700
Description Aim
Osteoarthritis (OA) is the most common chronic joint disorder, resulting from the breakdown of joint cartilage. It occurs in the knees, hands, and hips, leading to pain, stiffness, inflammation, and swelling.
Methods
In this study, 100 hand and knee OA patients, meeting the American College of Rheumatology criteria were included in the case group, and 100 healthy individuals were allocated to the control group. Blood samples were collected from the participants. After DNA extraction, genotyping was carried out for GDF5 rs143383 C/T polymorphism by allele-specific polymerase chain reaction (ASPCR) and for D-repeat alleles of asporin (ASPN) by conventional PCR assay.
Results
The results showed that the frequency of the D14 allele of ASPN was significantly higher than other alleles in the case group (P = .0001). Also, the frequency of the D14 allele among women was significantly higher than in men (P…
Total citations Cited by 3
2022 2023
Scholar articles Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat
polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran N Moghimi, S Nasseri, F Ghafouri, A Jalili – International Journal of Rheumatic Diseases, 2021
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