MT2-MMP is differentially expressed in multiple myeloma cells and mediates their growth and progression

MT2-MMP is differentially expressed in multiple myeloma cells and mediates their growth and progression
Authors Shohreh Fakhari, Ali Jalili, Bahram Nikkhoo, Bayazid Ghaderi, Mohammad Amin Boshagh, Sako Mirzaie, Mohammad Moradzad
Publication date 2022/4/1
Journal Cellular Signalling
Volume 92
Pages 110248
Publisher Pergamon
Description Objective
Membrane type-matrix metalloproteinases (MT-MMPs) are known as key regulators of cancer progression/metastasis. However, their roles in the growth and progression of multiple myeloma (MM) have not been yet elucidated. Methods and materials
The expression of 6 MT-MMPs in MM, B cell lines, and normal peripheral blood (PB) cells were measured by RT-PCR, qRT-PCR, flow cytometry, western blotting, and immunocytochemistry. B lymphocytes, CD197/CD138, and CD197/CD138+ cells, known as malignant plasma cells (MPC), were sorted from bone marrow (BM) aspirations of 10 MM patients, and MT2-MMP expression was examined in these cells using qRT-PCR, flow cytometry and immunohistochemistry, and western blotting. Moreover, the expression of MT2-MMP in BM biopsies from 13 normal individuals and 14 MM patients was analyzed by immunohistochemistry. MT2-MMP was also …
Total citations Cited by 1
2023
Scholar articles MT2-MMP is differentially expressed in multiple myeloma cells and mediates their growth and progression
S Fakhari, A Jalili, B Nikkhoo, B Ghaderi, MA Boshagh… – Cellular Signalling, 2022
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