T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer

T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer
Authors Mehrdad Fathi, Inna Pustokhina, Sergey V Kuznetsov, Mars Khayrullin, Mohammad Hojjat-Farsangi, Vahid Karpisheh, Ali Jalili, Farhad Jadidi-Niaragh
Publication date 2021/5
Source IUBMB life
Volume 73
Issue 5
Pages 726-738
Publisher John Wiley & Sons, Inc.
Description The importance of the tumor microenvironment in cancer progression has been well studied for many years. Immune checkpoint inhibitors (ICIs) are regarded as potential strategies in enhancing the immune responses in patients with cancer, particularly colorectal cancer (CRC). Notably, CRCs are extraordinarily heterogeneous and mostly are microsatellite-stable (MSS) or cold tumors, which means that the immune response is not usually as strong as that of foreign cells. T-cell immunoglobulin and ITIM domain (TIGIT) is a new immune checkpoint receptor overexpressed inside the CRC tumor- immune microenvironments. Moreover, several studies have shown that TIGIT in combination with other ICIs and/or conventional treatments, can lead to a robust anti- tumor response in CRC. This review looks deep inside TIGIT expression patterns, their various functions, and possible immunotherapy strategies to increase…
Total citations Cited by 15
2021 2022 2023
Scholar articles T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer
M Fathi, I Pustokhina, SV Kuznetsov, M Khayrullin… – IUBMB life, 2021
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