Anti-tumor activity of ferulago angulata Boiss. Extract in gastric cancer cell line via induction of apoptosis

Anti-tumor activity of ferulago angulata Boiss. Extract in gastric cancer cell line via induction of apoptosis
Authors Shafagh Heidari, Hassan Akrami, Roghaye Gharaei, Ali Jalili, Hamid Mahdiuni, Elham Golezar
Publication date 2014
Journal Iranian journal of pharmaceutical research: IJPR
Volume 13
Issue 4
Pages 1335
Publisher Brieflands
Description Ferulago angulata Boiss. known in Iran as Chavir, has some bioactive compounds
having antioxidant activity. Because of its antioxidant activities, it sounded Chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. In this study, the cytotoxic effects and proapoptotic activities of Chavir’s leaf and flower extracts were investigated on human adenocarcinoma gastric cell line (AGS). The ferric reducing antioxidant power (FRAP) assay was used to determine antioxidant activity of the extract. Cytotoxic effects of the extract were performed by trypan blue and neutral red assays. For apoptosis detection, we used Annexin V staining, flow cytometry and DNA fragmentation assays. The FRAP assay results showed that antioxidant activity of leaf extract was higher than flower extract. Cytotoxicity and apoptosis-inducing activity of flower and leaf extracts…
Total citations Cited by 34
Scholar articles Anti-tumor activity of ferulago angulata Boiss. Extract in gastric cancer cell line via induction of apoptosis
S Heidari, H Akrami, R Gharaei, A Jalili, H Mahdiuni… – Iranian journal of pharmaceutical research: IJPR, 2014
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