Complement C1q enhances homing-related responses of hematopoietic stem/progenitor cells

Authors Ali Jalili, Leah Marquez-Curtis, Neeta Shirvaikar, Marcin Wysoczynski, Mariusz Ratajczak, Anna Janowska-Wieczorek
Description BACKGROUND: Previously, we reported that the complement cleavage fragments C3a and C5a are important modulators of trafficking of hematopoietic stem/progenitor cells (HSPCs). The aim of this study was to examine a possible role for complement component 1, subcomponent q (C1q) in HSPC migration.
STUDY DESIGN AND METHODS: CD34+ HSPCs isolated from cord blood (CB), bone marrow (BM), and granulocyte-colony-stimulating factor (G-CSF)-mobilized peripheral blood (mPB) were evaluated for the expression of C1q and its receptor for phagocytosis (C1qRp) using reverse transcription-polymerase chain reaction, Western blotting, and fluorescence-activated cell sorting. Chemotactic responses and chemoinvasiveness toward stromal cell-derived factor (SDF)-1 and expression of matrix metalloproteinase (MMP)-9 were also examined after C1q stimulation. Moreover, G-CSF- and zymosan… Total citations Cited
Scholar articles Complement C1q enhances homing-related responses of hematopoietic stem/progenitor
cells
A Jalili, L Marquez-Curtis, N Shirvaikar, M Wysoczynski… – Transfusion, 2010 Cited by 31 Related articles All 10 versions