Human umbilical cord mesenchymal stem cells improve morphometric and histopathologic changes of cyclophosphamide-injured ovarian follicles in mouse model of premature ovarian …

Human umbilical cord mesenchymal stem cells improve morphometric and histopathologic changes of cyclophosphamide-injured ovarian follicles in mouse model of premature ovarian …
Authors Ladan Jalalie, Mohammad Ali Rezaee, Mohammad Jafar Rezaie, Ali Jalili, Amir Raoofi,
Auob Rustamzade
Publication date 2021/1/1
Journal Acta Histochemica
Volume 123
Issue 1
Pages 151658
Publisher Urban & Fischer
Description Background
Mesenchymal stem cells have restorative effects on premature ovarian failure (POF). The aim of this study was to investigate the effects of human umbilical cord vein MSCs (hUCV-MSCs) on follicular quantitative parameters and histological changes of ovaries in the cyclophosphamide (CTX)-induced POF in mice.
Materials and methods
C57BL/6 mice were divided into three groups (10 mice in each group). In the control group, phosphate-buffered saline (PBS) was injected via tail vein following 15 days injection of PBS intraperitoneally (IP). In the CTX group, CTX was administered IP for 15 days and then PBS was injected via tail vein. In the CTX+hUCV-MSCs group, following CTX administration, single dose of the 1x 106 of hUCV-MSCs were injected into tail vein. H&E, trichrome and PAS staining as well as TUNEL assay were performed on the ovaries tissue sections. The number of follicles…
Total citations Cited by 10
2021 2022 2023
Scholar articles Human umbilical cord mesenchymal stem cells improve morphometric and
histopathologic changes of cyclophosphamide-injured ovarian follicles in mouse model of premature ovarian failure
L Jalalie, MA Rezaee, MJ Rezaie, A Jalili, A Raoofi… – Acta Histochemica, 2021 Cited by 10 Related articles All 5 versions